You are here:Home/News/News/New Publication – Validation of extracellular ligand–receptor interactions b...
Validation of extracellular ligand–receptor interactions by Flow-TriCEPS
In our publication https://rdcu.be/bcFxH we show how the TriCEPS platforms (Flow-TriCEPS / LRC-TriCEPS) are used for optimizing the binding conditions for your ligand of interest to living cells, how the identification of the unknown targets is performed and how the identified target candidates are confirmed in a fast and inexpensive way. We show three examples of a peptide ligand, a protein ligand and an antibody.
Using Flow-TriCEPS to confirm the identified targets. Example here showing Transferrin-TriCEPS binding to MDA-MD-231 cells. Binding is reduced when the target receptor (Transferrin receptor) is down regulated by siRNA treatment in a time dependent manner.
Click on the different category headings to find out more. You can also change some of your preferences. Note that blocking some types of cookies may impact your experience on our websites and the services we are able to offer.
Essential Website Cookies
These cookies are strictly necessary to provide you with services available through our website and to use some of its features.
Because these cookies are strictly necessary to deliver the website, you cannot refuse them without impacting how our site functions. You can block or delete them by changing your browser settings and force blocking all cookies on this website.
Other external services
We also use different external services like Google Webfonts, Google Maps and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.
Google Webfont Settings:
Google Map Settings:
Vimeo and Youtube video embeds:
Transport not incl. Your Information will never be shared with any third party.
To get pretest TriCEPS Material please contact us!
Identify the targets of your ligand on the living cells. Prior to the main experiment get free TriCEPS Material to test the functionality of your TriCEPS coupled ligand.