Binding to carboxypeptidase M mediates protective effects of fibrinopeptide Bβ
November 01, 2019
Intro
https://doi.org/10.1016/j.trsl.2019.07.008, Translational Research Volume 213, Sörensen-Zender et al.Abstract
A 28-amino-acid fibrinopeptide (Bb15-42) was studied for kidney protection using human HK-2 tubular cells. The LRC-TriCEPS platform enabled the discovery of carboxypeptidase M (CBPM) as a novel cell surface receptor for Bb15-42, revealing a new protective mechanism independent of endothelial VE-cadherin. This work is important as it identifies CBPM as a therapeutic target for renal injury, illustrating the unique power of LRC-TriCEPS to uncover receptor-ligand interactions directly on living cells.Author
Inga Sörensen-Zender soerensen.inga@mh-hannover.de ∙ Rongjun Chen ∙ Song Rong ∙ Sascha David ∙ Anette Melk ∙ Hermann Haller∙ Roland Schmitt from Hannover Medical SchoolFooter
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