University Hospital of Lausanne (CHUV)

University Hospital of Lausanne (CHUV)

We collaborated with DualSystems Biotech AG to perform LRC-TriCEPS experiments aimed at identifying cellular factors involved in Zika virus infection. The entire process—from initial discussions through to data delivery—was carried out with exceptional professionalism and scientific rigor. Thanks to their LRC-TriCEPS platform, we were able to identify a cellular factor playing a major role in Zika virus entry. This unique method was applied to living cells without the need for genetic modification. In our case, the method worked robustly across three different cell types. Notably, it enabled the identification of an unexpected target at the cell surface that would likely have been missed by standard screening approaches, as the protein lacks a classical membrane anchor. What impressed us most was that the implication of this target, discovered via their screening, was subsequently confirmed in our in vitro studies using different cellular models. We greatly appreciated the collaboration with the DualSystems Biotech AG team. Their expertise, responsiveness, and willingness to support our project at every stage were key to its success. The data provided were of high quality and well presented, facilitating downstream interpretation and validation. Milos Stojanov, PhD - Head of the Materno-fetal and Obstetrics Research Unit - University Hospital of Lausanne (CH)   Miloš Stojanov, PhD | Senior Lecturer (MER1) Head of the Materno-fetal and Obstetrics Research Unit Department Woman-mother-child (DFME) 1011 Lausanne Tél: +41 21 314 05 17
2025-04-04T12:42:13+00:00