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Direct identification of ligand-receptor interactions on living cells and tissues

September 16, 2012

Reference

Nature Biotechnology 30, 997–1001 doi:10.1038/nbt.2354 – ReceivedAccepted Published online

Abstract

Here we describe our LRC- TRICEPS platform to identify targets on living cells. We validated this ligand-based, receptor-capture (LRC) technology using different peptides, proteins, antibodies, biologics and viruses. This technology enables the identification of receptors for many types of ligands under near-physiological conditions and without the need for genetic manipulations.

Author

Andreas P Frei, Ock-Youm Jeon, Samuel Kilcher, Hansjoerg Moest, Lisa M Henning, Christian Jost, Andreas Plückthun, Jason Mercer, Ruedi Aebersold, Erick M Carreira & Bernd Wollscheid

A Mass Spectrometric-Derived Cell Surface Protein AtlasLigand-based receptor identification on living cells and tissues using TRIC...
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  • Extracellular proteins
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  • Viruses
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  • Small molecules
  • Extracellular proteins
  • Peptide ligands
  • Antibodies
  • Engineered affinity binders
  • Viruses