Drug repositioning
Turn old drugs into new ones - drug profiling or repositioning
- Drug repositioning concerns the development of either discontinued or off-patent drugs for novel indications, something that has historically tended to occur by serendipity
- Drug repositioning relies on biological redundancy: either a biological
target functions in several physiological pathways or drugs have multiple
uncharacterized off-target effects - Because repositioned drugs already have undergone extensive toxicological and pharmacokinetic studies, their development for a novel indication is associated with considerably reduced risk, cost and time compared with conventional discovery
- Current market conditions and pipeline issues are driving the adoption of repositioning as a bone fide drug discovery process
Key benefits of our drug repositioning platform
Our drug repositioning platforms help you understand the mechanism of action of drug candidates and to identify potential off-target effects. Our data delivers valuable insights into potentially novel indications for established drugs or drugs under development.
- The use of multiple independent screening platforms ensures highly accurate data
- All classes of protein targets are accessible, including cell surface receptors
- Small molecule – target interactions take place in an intact cellular environment
