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Services

CaptiRec Services


Ligand-receptor capture technology (LRC-TriCEPS™)

A novel approach to analyse extracellular cell signaling by discovering cell surface receptors and off-targets for a ligand of interest on the living cell: label ligand with the LRC-TriCEPS™crosslinker, incubate with living cells or tissue expressing target receptor(s), purify receptor crosslinked peptides, analyse by LC-MS/MS. This new technology was invented by Andreas Frei and Bernd Wollscheid from the ETH Zurich who published the technology in Nature Biotechnology (Frei et al.(2012) Nature Biotechnology 30:997-1001).

Orphan ligands:

Ligand-receptor

  • Extracellular proteins
  • Peptide ligands
  • Antibodies
  • Viruses
  • Engineered affinity binders

CaptiRec Services (extracellular cell interaction of the living cell)

CaptiRec Services


proteomics_services

Identification of protein complexes and protein interactions in mammalian cells using a tagged bait

CaptiVate Shotgun Proteomics Services using  LC-MS/MS

  • Identification of protein complexes and protein interactions in mammalian cells
  • Profiling of signaling pathways
  • analysis of post-translational modifications

CaptiVate Services (intracellular signaling on stimuli)