Specialists for ligand-receptor capture technology

LRC-TriCEPS-Video

How LRC TriCEPS™ technology works

Vulcano-Plot-on-protein-level

Example of a CaptiREC (LRC-TriCEPS)

experiment performed at Dualsystems

to identify the target receptor of

Anti-EGFR-Antibody on human

breast cancer cells (MDA-MB-231)

CaptiRec Services detection of extracellular cell interactions 

A conceptual novel approach for ligand-receptor capture on the living cell

TriCEPS™-based ligand-receptor capture (LRC-TriCEPS™) is a novel technology. LRC-TriCEPS™ enables the unbiased identification of cell surface receptors and off-targets on the living cells without genetic manipulation. Ligand-receptor capture technology can be used for many types of orphan ligands, such as peptides, proteins, antibodies, engineered affinity binders but also for viruses.

Orphan ligands:

  • Extracellular proteins
  • Peptide ligands
  • Antibodies
  • Engineered affinity binders
  • Viruses

Dualsystems provides full analytical Services. After the method transfer a full LRC-TriCEPS™ Kit is available.

Do you want to do functional pretests with your ligand coupled to TriCEPS™?

Ask for the pretest TriCEPS™ Kit. Here

NEW! Example of a CaptiREC (LRC-TriCEPS) experiment performed at Dualsystems to identify the target receptor of Anti-EGFR-Antibody on human breast cancer cells (MDA-MB-231)

Video how the LRC-TriCEPS™ technology works

Video Interview about CaptiRec Services, ligand-receptor capture technology (LRC-TriCEPS) on the living cell


CaptiVate Services detection of intracellular signaling on stimuli

Identification of protein complexes and protein interactions in mammalian cells

Unique service workflow produces complete data set. Identify all protein partners of your bait and monitor protein interactions in response to drugs / extra-cellular stimuli and map post-translational modifications based on affinity purification using a streptavidin tag.

Learn more about CaptiVate Services


About Dualsystems Biotech AG

Dualsystems Biotech - Swiss-QualityDualsystems Biotech is a service provider for custom proteomics for industry and academia. We are specialized in elucidating the interaction of the living cell with extracellular ligands using the ligand-receptor capture LRC-TriCEPS™ technology. For the intracellular signaling we provide the CaptiVate Services using affinity purification/mass spectrometry analysis of protein complexes. Further, we provide Shotgun Proteomics Services for proteins / peptides (LC-MS/MS services) and stable cell line generation for human (HEK, Jurkart), mouse NIH 3T3 and chinese hamster ovary (CHO) cells.

 

NEW – LRC TriCEPS™ VIDEO

References Service CaptiRec

De'Broski R. Herbert Ph.D.
Assistant Professor in Residence
University of California San Francisco (UCSF)

"We have been trying to identify a receptor that has been sought after for nearly 30 years by laboratories across the globe. Thanks to Dualsystems service CaptiRec (LRC-TriCEPS), we now have a strong candidate receptor."

Contact us

+41 44 738 50 00

The TriCEPS™-based ligand-receptor capture technology is now available.
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CaptiRec Services Video

CaptiRec Services, ligand-receptor capture technology (LRC). Interview with Dr. Paul Helbling

Video LRC

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